Early onset first episode psychosis: dimensional structure of symptoms, clinical subtypes and related neurodevelopmental markers

Markers of neurodevelopmental impairments in early-onset psychosis

BACKGROUND The aim of this study was to assess the association between the clinical and neurobiological markers of neurodevelopmental impairments and early-onset schizophrenia spectrum psychosis. METHODS A sample of 36 patients with early-onset schizophrenia spectrum psychosis was compared to a control sample of 36 patients with migraine. We assessed early childhood neurodevelopmental milesto...

Premorbid Negative Symptoms in First-Episode Psychosis

Background and Objectives: Negative symptoms emerge in many patients with psychotic disorders long before the onset of the acute illness. These symptoms are often impossible to differentiate from certain Cluster A personality traits. Methods: The current study examines the extent to which premorbid negative symptoms are contributing factors to the development of primary and secondary negative s...

Early intervention for first episode psychosis.

Clinical Recovery in First-Episode Psychosis

INTRODUCTION Generally agreed outcome criteria in psychosis are required to evaluate the effectiveness of new treatment strategies. The aim of this study is to explore clinical recovery in first-episode patients, defined by meeting criteria for both symptomatic and functional remission. METHOD In a sample of first-episode patients (N = 125), symptomatic and functional remission during the las...

Manic and depressive symptoms and insight in first episode psychosis.

Insight impairment is common early in the course of psychosis. Most studies have focused on the relationship between insight and depression, although manic symptoms are also frequent in psychoses. The main aim of this study was to examine the relationship between insight dimensions and manic and depressive symptoms in first-episode psychosis. A group of inpatients in their first psychotic episo...